Liu S Q, Liu X F, Song S J
Union Hospital, Tongji Medical University, Wuhan, Hubei.
Zhonghua Bing Li Xue Za Zhi. 1994 Oct;23(5):288-90.
An immunohistochemical study was performed on trephine biopsy specimens of bone marrow in 10 patients with myelodysplastic syndromes (MDS). Monoclonal antibodies HIP7 and CDW41 were used against platelet glycoprotein IIb/IIIa (CD41) to determine dysmegakaryopoiesis including its size, proportion of micromegakaryocytes, location and staining characteristics. The results show that the dysmegakaryopoiesis of MDS includes the increased number and high proportion of micromegakaryocytes, the altered architectural distribution and the considerable variation in staining. These may be helpful in the diagnosis and differential diagnosis of MDS.
对10例骨髓增生异常综合征（MDS）患者的骨髓环钻活检标本进行了免疫组织化学研究。使用单克隆抗体HIP7和CDW41针对血小板糖蛋白IIb/IIIa（CD41），以确定巨核细胞生成异常，包括其大小、微巨核细胞比例、位置和染色特征。结果显示，MDS的巨核细胞生成异常包括微巨核细胞数量增加和比例升高、结构分布改变以及染色的显著变化。这些可能有助于MDS的诊断和鉴别诊断。
