Zhang J Z, Fan S C, Liu H F
Department of Pathology, General Hospital, Lanzhou Military Command.
Zhonghua Bing Li Xue Za Zhi. 1994 Oct;23(5):302-3.
The level of P21 protein in 40 breast carcinomas, 37 benign tumors and 52 proliferative breast diseases in females were determined by the ABC immunohistochemical method. The positive rate was 72.5%, 32.43% and 23.07% respectively. The positive expressions were mainly found in tumor cells in poorly differentiated infiltrating ductal carcinomas and in 3 of the 5 proliferative breast disease cases with atypical hyperplasia of ductal epithelium, suggesting that P21 protein detection could provide a molecular biological basis for the evaluation of malignant changes and the prognosis of mammary lesions.
采用ABC免疫组织化学方法检测40例女性乳腺癌、37例乳腺良性肿瘤及52例乳腺增生性疾病组织中P21蛋白的表达水平。其阳性率分别为72.5%、32.43%和23.07%。阳性表达主要见于低分化浸润性导管癌的肿瘤细胞以及5例伴有导管上皮不典型增生的乳腺增生性疾病中的3例，提示P21蛋白检测可为乳腺病变的恶变及预后评估提供分子生物学依据。
