Bush V J, Moyer T P, Batts K P, Parisi J E
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905.
Clin Chem. 1995 Feb;41(2):284-94.
The concentrations of five essential elements and six potentially toxic elements were determined in seven organs collected at autopsy from 30 human subjects. Elemental analyses were carried out by graphite furnace atomic absorption spectroscopy, and inductively coupled plasma emission spectroscopy, and inductively coupled plasma mass spectroscopy, and concentrations in fresh and formalin-fixed tissues were compared. Formalin-fixation long-term storage has little effect on most element concentrations in tissue, except for Al and Mn, which changed with prolonged storage in formalin. The kidney and liver contained the greatest concentrations of toxic elements compared with other organs, whereas the essential elements were uniformly distributed among all organs. There was no more than a 10-fold difference in the tissue concentration of the elements studied among the organs, except for the concentration of Fe in liver, and Ca and Mg in bone. We also demonstrate that these elements are homogeneously distributed in tissues.
测定了30名人类受试者尸检时采集的七个器官中五种必需元素和六种潜在有毒元素的浓度。通过石墨炉原子吸收光谱法、电感耦合等离子体发射光谱法和电感耦合等离子体质谱法进行元素分析，并比较了新鲜组织和福尔马林固定组织中的浓度。福尔马林固定长期保存对组织中大多数元素的浓度影响不大，除了铝和锰，它们在福尔马林中长时间保存会发生变化。与其他器官相比，肾脏和肝脏中有毒元素的浓度最高，而必需元素在所有器官中分布均匀。除肝脏中的铁浓度以及骨骼中的钙和镁浓度外，所研究元素在各器官中的组织浓度差异不超过10倍。我们还证明这些元素在组织中均匀分布。
