al-Arafaj A, Ryan E A, Hutchison K, Mannan R H, Mercer J, Wiebe L I, McEwan A J
University of Alberta Hospitals, Edmonton, Canada.
Eur J Nucl Med. 1994 Dec;21(12):1338-42. doi: 10.1007/BF02426699.
Peripheral vascular disease is a serious and common complication in patients with diabetes mellitus (DM). Evaluation is, conventionally, by transcutaneous oxygen tension measurements (TcpO2), although this technique has some limitations in the evaluation of tissue viability. We have evaluated a new, radiolabelled, in vivo marker of tissue hypoxia, iodoazomycinarabinoside (IAZA), by comparing TcpO2 measurements with patterns of iodine-123 IAZA uptake in ten patients (19 lower limbs) with DM and peripheral vascular disease using conventional gamma camera imaging techniques. Normal uptake patterns were seen in limbs in which normal TcpO2 measurements were obtained. Diffusely increased uptake of [123I]IAZA was seen in limbs with reduced TcpO2. Focally increased uptake was seen in ulcers or in areas of atrophic skin change. A semi-quantitative measure showed an inverse correlation between [123I]IAZA and TcpO2 values. These data suggest that tissue hypoxia can be imaged in this population of patients and that severity of disease can be assessed. A longitudinal prospective trial is now being developed.
外周血管疾病是糖尿病（DM）患者中一种严重且常见的并发症。传统上，通过经皮氧分压测量（TcpO2）进行评估，尽管该技术在评估组织活力方面存在一些局限性。我们通过使用传统伽马相机成像技术，比较10例患有糖尿病和外周血管疾病的患者（19条下肢）的TcpO2测量值与碘-123碘阿糖胞苷（IAZA）摄取模式，评估了一种新的、放射性标记的体内组织缺氧标志物——碘阿糖胞苷（IAZA）。在获得正常TcpO2测量值的肢体中观察到正常摄取模式。在TcpO2降低的肢体中，观察到[123I]IAZA摄取弥漫性增加。在溃疡或皮肤萎缩改变区域观察到局部摄取增加。半定量测量显示[123I]IAZA与TcpO2值呈负相关。这些数据表明，在这类患者中可以对组织缺氧进行成像，并且可以评估疾病的严重程度。目前正在开展一项纵向前瞻性试验。
