Hauser C J, Klein S R, Mehringer C M, Appel P, Shoemaker W C
Diabetes. 1984 Jun;33(6):527-31. doi: 10.2337/diab.33.6.527.
Regional transcutaneous oximetry is a new, noninvasive diagnostic technique for the investigation of peripheral vascular disease (PVD) that uses differences in limb and trunk transcutaneous PO2 to assess the adequacy of local perfusion. The application of such measurements would be of great importance in diabetes, in which limb ischemia is commonly difficult to assess. A group of diabetic subjects with symptomatic PVD was studied with regional oximetry, Doppler-assisted blood pressure measurements, and arteriography. Doppler studies correlated poorly to symptom grade and angiographic data, while oximetry clearly demonstrated limb hypoxia under the functional conditions appropriate to the patients' clinical symptomatology. The superiority of oximetry to Doppler studies was highly significant (X2 = 12.64, P less than 0.001). Regional transcutaneous oximetry should therefore be the noninvasive diagnostic test of choice in the initial evaluation of the diabetic limb for PVD. Because of its dependence on the adequacy of local oxygenation, transcutaneous oximetry is a powerful tool for investigation of the pathophysiology of PVD and will, in the future, have wide-ranging applications to the diagnosis and therapy of PVD.
区域经皮血氧测定法是一种用于研究外周血管疾病（PVD）的新型非侵入性诊断技术，它利用肢体和躯干经皮血氧分压的差异来评估局部灌注是否充足。这种测量方法的应用在糖尿病中具有重要意义，因为糖尿病患者的肢体缺血通常难以评估。一组有症状的PVD糖尿病患者接受了区域血氧测定、多普勒辅助血压测量和动脉造影检查。多普勒研究与症状分级和血管造影数据的相关性较差，而血氧测定法在适合患者临床症状的功能条件下清楚地显示了肢体缺氧。血氧测定法相对于多普勒研究的优越性非常显著（X2 = 12.64，P小于0.001）。因此，区域经皮血氧测定法应成为糖尿病肢体PVD初始评估中首选的非侵入性诊断测试。由于其依赖于局部氧合的充足性，经皮血氧测定法是研究PVD病理生理学的有力工具，并且在未来将广泛应用于PVD的诊断和治疗。
