Bourinbaiar A S, Lee-Huang S
Department of Biochemistry, New York University Medical Center, NY 10016.
FEBS Lett. 1995 Feb 20;360(1):85-8. doi: 10.1016/0014-5793(95)00057-g.
Indomethacin, a common non-steroidal anti-inflammatory drug (NSAID), has been used to treat rheumatoid arthritis. Although indomethacin has also been used as an immunopotentiator and symptomatic NSAID in AIDS, its effect on HIV replication is unknown. MT-4 lymphocytes were inoculated with HIV in the presence of indomethacin and tested for p24 expression by ELISA. The 50% inhibition (IC50) was 10 microM, corresponding to plasma levels after administration of 50 mg oral indomethacin. The antiviral effect appears to be specific since no toxicity has been observed at the IC50 dose, and unrelated NSAIDs have not shown the activity at clinical doses. Indomethacin may, thus, represent a new class of anti-HIV drug.
吲哚美辛是一种常见的非甾体抗炎药（NSAID），已被用于治疗类风湿性关节炎。虽然吲哚美辛也被用作艾滋病患者的免疫增强剂和对症NSAID，但其对HIV复制的影响尚不清楚。在吲哚美辛存在的情况下，用HIV接种MT-4淋巴细胞，并通过ELISA检测p24表达。50%抑制率（IC50）为10微摩尔，相当于口服50毫克吲哚美辛后的血浆水平。抗病毒作用似乎具有特异性，因为在IC50剂量下未观察到毒性，且无关的NSAID在临床剂量下未显示出该活性。因此，吲哚美辛可能代表一类新型抗HIV药物。
