超氧阴离子和过氧化氢对离体猫脑动脉和肺动脉内皮功能的不同影响。
Different influence of superoxide anions and hydrogen peroxide on endothelial function of isolated cat cerebral and pulmonary arteries.
作者信息
Fraile M L, Conde M V, Sanz L, Moreno M J, Marco E J, López de Pablo A L
机构信息
Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Spain.
出版信息
Gen Pharmacol. 1994 Oct;25(6):1197-205. doi: 10.1016/0306-3623(94)90138-4.
PMID:7875545
Abstract
- Exogenous superoxide dismutase (SOD) or catalase did not modify isolated cat middle cerebral arterial basal tone. Catalase but not SOD reduced ACh relaxation. 2. H2O2 induced endothelium-independent relaxation which was abolished by catalase. 3. 3-Amino-1,2,4-triazole (AT) evoked endothelium-dependent contractions and diminished ACh relaxation. 4. Diethyldithio carbamic acid (DETC) induced endothelium-independent relaxation and did not modify ACh vasodilatation. 5. ACh relaxation of cat isolated pulmonary arteries was unaffected by SOD, catalase or AT, and diminished by DETC. 6. Endothelial catalase but neither SOD nor superoxide anions is involved in EDRF cerebral vasodilatation and H2O2 participates in ACh relaxation. In pulmonary arteries, only endothelial SOD activity plays a role.
摘要
- 外源性超氧化物歧化酶（SOD）或过氧化氢酶不会改变离体猫大脑中动脉的基础张力。过氧化氢酶可降低乙酰胆碱（ACh）介导的舒张反应，但SOD无此作用。2. 过氧化氢（H2O2）可诱导非内皮依赖性舒张反应，此反应可被过氧化氢酶消除。3. 3-氨基-1,2,4-三唑（AT）可引发内皮依赖性收缩，并减弱ACh介导的舒张反应。4. 二乙基二硫代氨基甲酸盐（DETC）可诱导非内皮依赖性舒张反应，且不改变ACh介导的血管舒张作用。5. SOD、过氧化氢酶或AT对猫离体肺动脉的ACh介导的舒张反应无影响，但DETC可减弱此反应。6. 内皮过氧化氢酶而非SOD或超氧阴离子参与了内皮依赖性舒张因子（EDRF）介导的脑血管舒张反应，H2O2参与了ACh介导的舒张反应。在肺动脉中，仅内皮SOD活性发挥作用。
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