Loviselli A, Calia M A, Murenu S, Mossa P, Cambosu M A, Caradonna A
Institute of Internal Medicine, University of Cagliari, Italy.
Horm Metab Res. 1994 Nov;26(11):548-51. doi: 10.1055/s-2007-1001754.
In hypothyroid patients serum soluble IL-2 receptor levels showed scattered and conflicting results. In our report we studied circulating soluble interleukin 2 receptors in 22 patients with hypothyroid autoimmune thyroiditis before L-thyroxine treatment and when the patients became euthyroid. The mean of soluble Interleukin 2 receptor levels in the hypothyroid state was 48.6 pmol/l (95% confidence interval, 45.6-51.5) statistically lower than in the controls (95% confidence interval, 86.4 pmol/l, 83.3-89.4) (p < 0.0001). When the patients became euthyroid during L-thyroxine treatment, soluble Interleukin 2 receptor levels increased, showing mean values comparable to the controls. A positive high correlation (p < 0.001) was observed between soluble Interleukin 2 receptor levels and thyroxine free levels in the hypothyroid as well as in the euthyroid state and between soluble Interleukin 2 receptors and the mean weekly L-thyroxine dose. Our study confirmed that in the hypothyroid state, the behaviour of soluble Interleukin 2 receptors is anomalous as compared to other autoimmune diseases. In fact a strict relationship exists between the levels of thyroid hormones and soluble Interleukin 2 receptors but not between the latter and antithyroid antibodies. These results agree with those supporting a role for thyroid hormones in the regulation of the immune system. They also suggest that the measurement of soluble Interleukin 2 receptors could be used as a marker of the peripheral action of thyroid hormones.
在甲状腺功能减退患者中，血清可溶性白细胞介素-2受体水平的结果参差不齐且相互矛盾。在我们的报告中，我们研究了22例自身免疫性甲状腺炎伴甲状腺功能减退患者在左甲状腺素治疗前及甲状腺功能恢复正常时循环可溶性白细胞介素-2受体的情况。甲状腺功能减退状态下可溶性白细胞介素-2受体水平的平均值为48.6 pmol/l（95%置信区间，45.6 - 51.5），统计学上低于对照组（95%置信区间，86.4 pmol/l，83.3 - 89.4）（p < 0.0001）。当患者在左甲状腺素治疗期间甲状腺功能恢复正常时，可溶性白细胞介素-2受体水平升高，显示出与对照组相当的平均值。在甲状腺功能减退以及甲状腺功能正常状态下，可溶性白细胞介素-2受体水平与游离甲状腺素水平之间以及可溶性白细胞介素-2受体与每周左甲状腺素平均剂量之间均观察到高度正相关（p < 0.001）。我们的研究证实，与其他自身免疫性疾病相比，在甲状腺功能减退状态下，可溶性白细胞介素-2受体的表现异常。事实上，甲状腺激素水平与可溶性白细胞介素-2受体之间存在密切关系，但后者与抗甲状腺抗体之间不存在这种关系。这些结果与支持甲状腺激素在免疫系统调节中起作用的观点一致。它们还表明，可溶性白细胞介素-2受体的测量可作为甲状腺激素外周作用的标志物。
