转化生长因子β1作为肺腺癌的预后因素
Transforming growth factor beta 1 as a prognostic factor in pulmonary adenocarcinoma.
作者信息
Takanami I, Imamura T, Hashizume T, Kikuchi K, Yamamoto Y, Kodaira S
机构信息
Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.
出版信息
J Clin Pathol. 1994 Dec;47(12):1098-100. doi: 10.1136/jcp.47.12.1098.
AIMS
To evaluate the efficacy of transforming growth factor beta (TGF-beta) for the prognosis of pulmonary adenocarcinoma.
METHODS
TGF-beta was detected immunohistochemically using the avidin-biotin-peroxidase complex technique in resected pulmonary adenocarcinomas from 88 patients.
RESULTS
Of the 88 patients, 39 were TGF-beta negative and 45 TGF-beta positive. The five year survival rate was 56% for the TGF-beta negative and 16% for the TGF-beta positive group.
CONCLUSIONS
TGF-beta can be used as a prognostic factor in pulmonary adenocarcinoma.
目的
评估转化生长因子β（TGF-β）对肺腺癌预后的影响。
方法
采用抗生物素蛋白-生物素-过氧化物酶复合物技术对88例肺腺癌切除标本进行TGF-β免疫组化检测。
结果
88例患者中，39例TGF-β阴性，45例TGF-β阳性。TGF-β阴性组的五年生存率为56%，TGF-β阳性组为16%。
结论
TGF-β可作为肺腺癌的预后因素。
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