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转化生长因子β1作为肺腺癌的预后因素

Transforming growth factor beta 1 as a prognostic factor in pulmonary adenocarcinoma.

作者信息

Takanami I, Imamura T, Hashizume T, Kikuchi K, Yamamoto Y, Kodaira S

机构信息

Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.

出版信息

J Clin Pathol. 1994 Dec;47(12):1098-100. doi: 10.1136/jcp.47.12.1098.

DOI:10.1136/jcp.47.12.1098
PMID:7876382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC502200/
Abstract

AIMS

To evaluate the efficacy of transforming growth factor beta (TGF-beta) for the prognosis of pulmonary adenocarcinoma.

METHODS

TGF-beta was detected immunohistochemically using the avidin-biotin-peroxidase complex technique in resected pulmonary adenocarcinomas from 88 patients.

RESULTS

Of the 88 patients, 39 were TGF-beta negative and 45 TGF-beta positive. The five year survival rate was 56% for the TGF-beta negative and 16% for the TGF-beta positive group.

CONCLUSIONS

TGF-beta can be used as a prognostic factor in pulmonary adenocarcinoma.

摘要

目的

评估转化生长因子β（TGF-β）对肺腺癌预后的影响。

方法

采用抗生物素蛋白-生物素-过氧化物酶复合物技术对88例肺腺癌切除标本进行TGF-β免疫组化检测。

结果

88例患者中，39例TGF-β阴性，45例TGF-β阳性。TGF-β阴性组的五年生存率为56%，TGF-β阳性组为16%。

结论

TGF-β可作为肺腺癌的预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9c/502200/f813338cc1c6/jclinpath00225-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9c/502200/f813338cc1c6/jclinpath00225-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9c/502200/f813338cc1c6/jclinpath00225-0043-a.jpg

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