Asakura S, Kato H, Fujino S, Konishi T, Asada Y, Tezuka N, Mori A
Second Department of Surgery, Shiga University of Medical Science, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1995 Dec;43(12):1924-8.
Transforming growth factor-beta (TGF-beta) is known as the growth factor that stimulates the multiplication and accumulation of extracellular matrix. Recently, TGF-beta also has been found to have the ability to control the growth and metastatic potential of cancer cells. It is known that central fibrosis frequently occurs in pulmonary adenocarcinoma and the prognosis becomes poorer as fibrosis become more hyalinized. To estimate the role of TGF-beta in the formation of central fibrosis in pulmonary adenocarcinoma and its influence on the prognosis of patients with pulmonary adenocarcinoma, we performed an immunohistochemical study of TGF-beta in 51 cases of T1 pulmonary adenocarcinoma. Positive stain for TGF-beta was shown in 31 cases, and negative stain was shown in 20 cases. In patients with Stage I, T1 pulmonary adenocarcinoma, the post operative survival curve was compared between positive and negative cases of TGF-beta, and the result showed a tendency toward poorer prognosis in positive cases of TGF-beta. Twenty-four of 51 cases of T1 pulmonary adenocarcinoma had central fibrosis. Twenty of 24 cases with central fibrosis showed positive stain for TGF-beta. It was proven that the appearance of central fibrosis was significantly related to positive stain for TGF-beta in T1 pulmonary adenocarcinoma. According to these results, it is suggested that TGF-beta plays some role in the formation of central fibrosis in pulmonary adenocarcinoma and TGF-beta is possibly a prognostic factor for patients with pulmonary adenocarcinoma.
转化生长因子-β（TGF-β）是一种刺激细胞外基质增殖和积聚的生长因子。最近，还发现TGF-β具有控制癌细胞生长和转移潜能的能力。已知中央纤维化在肺腺癌中经常出现，并且随着纤维化变得更加透明化，预后会变差。为了评估TGF-β在肺腺癌中央纤维化形成中的作用及其对肺腺癌患者预后的影响，我们对51例T1期肺腺癌患者进行了TGF-β的免疫组织化学研究。31例显示TGF-β阳性染色，20例显示阴性染色。在I期T1期肺腺癌患者中，比较了TGF-β阳性和阴性病例的术后生存曲线，结果显示TGF-β阳性病例的预后有较差的趋势。51例T1期肺腺癌中有24例有中央纤维化。24例有中央纤维化的病例中有20例显示TGF-β阳性染色。已证实T1期肺腺癌中中央纤维化的出现与TGF-β阳性染色显著相关。根据这些结果，提示TGF-β在肺腺癌中央纤维化形成中起一定作用，并且TGF-β可能是肺腺癌患者的一个预后因素。
