Takanami I, Tanaka F, Hashizume T, Kodaira S
First Department of Surgery, Taikyo University School of Medicine, Tokyo, Japan.
J Surg Oncol. 1997 Apr;64(4):262-7. doi: 10.1002/(sici)1096-9098(199704)64:4<262::aid-jso3>3.0.co;2-7.
In the United States, pulmonary adenocarcinomas have recently replaced squamous cell carcinomas as the most frequent type of lung cancer encountered. The incidence of pulmonary adenocarcinoma continued to increase worldwide.
To determine the roles of the transforming growth factor-beta 1 (TGF-beta 1), and TGF-beta type I receptor (T beta R-I), and the TGF-beta type II receptor (T beta R-II) in the progression of a pulmonary adenocarcinoma, their respective expressions have been immunohistologically studied in specimens from 120 pulmonary adenocarcinoma patients.
The overall prognosis was significantly poorer for patients showing positive TGF-beta 1, T beta R-I, T beta R-II expressions than for patients who were negative to all three immunostainings (P < 0.01). Our multivariate analysis also revealed that a positive TGF-beta 1 response significantly affect prognosis (P < 0.05).
TGF-beta 1, T beta R-I, and T beta R-II play important roles in tumor progression, and a positive TGF-beta 1 expression can serve as a pulmonary adenocarcinoma marker. T beta R-I and T beta R-II expressions are necessary for TGF-beta signal transduction.
在美国，肺腺癌最近已取代鳞状细胞癌，成为最常见的肺癌类型。肺腺癌的发病率在全球范围内持续上升。
为了确定转化生长因子-β1（TGF-β1）、TGF-βⅠ型受体（TβR-Ⅰ）和TGF-βⅡ型受体（TβR-Ⅱ）在肺腺癌进展中的作用，对120例肺腺癌患者的标本进行了免疫组织化学研究，以检测它们各自的表达情况。
TGF-β1、TβR-Ⅰ、TβR-Ⅱ表达呈阳性的患者总体预后明显比三项免疫染色均为阴性的患者差（P < 0.01）。我们的多变量分析还显示，TGF-β1阳性反应对预后有显著影响（P < 0.05）。
TGF-β1、TβR-Ⅰ和TβR-Ⅱ在肿瘤进展中起重要作用，TGF-β1阳性表达可作为肺腺癌的一个标志物。TβR-Ⅰ和TβR-Ⅱ的表达是TGF-β信号转导所必需的。
