Donta S T, Tomicic T K, Donohue-Rolfe A
Department of Medicine, Boston University Medical Center, MA 02118.
J Infect Dis. 1995 Mar;171(3):721-4. doi: 10.1093/infdis/171.3.721.
The effects of Shiga-like toxins on the morphology and protein synthetic capability of HeLa cells in tissue culture could be prevented by brefeldin A, an inhibitor of certain intracellular Golgi functions. Brefeldin A was without effect on the binding of Shiga-like toxin to cells. These results provide evidence that the Shiga-like toxins are first processed by the Golgi before moving to their 60S ribosome target site.
志贺样毒素对组织培养中HeLa细胞形态和蛋白质合成能力的影响可被布雷菲德菌素A（一种特定细胞内高尔基体功能的抑制剂）所阻止。布雷菲德菌素A对志贺样毒素与细胞的结合没有影响。这些结果证明，志贺样毒素在转移至其60S核糖体靶位点之前首先由高尔基体进行加工处理。
