Bramham J, Riddell F G
School of Chemistry, University of St. Andrews, Scotland.
J Inorg Biochem. 1995 Jan;57(1):23-32. doi: 10.1016/0162-0134(94)00010-8.
The membrane phospholipids and membrane proteins from the erythrocytes of manic depressive patients undergoing lithium therapy and of normal controls were examined by high performance TLC and gel electrophoresis, respectively. The phospholipid composition of the erythrocyte membranes of the normal controls was close to that reported previously. The lipid composition of the erythrocyte membranes of the patients was very similar but differed from the normal controls in that the proportion of sphingomyelin and cholesterol appeared to be lower, whereas phosphatidylserine appeared to be higher in the patients by amounts comparable with the sums of the 95% confidence limits on the measurements. No major differences in the protein composition of the erythrocyte membranes were detected.
分别采用高效薄层色谱法和凝胶电泳法对接受锂治疗的躁郁症患者及正常对照者红细胞的膜磷脂和膜蛋白进行了检测。正常对照者红细胞膜的磷脂组成与先前报道的相近。患者红细胞膜的脂质组成与之非常相似，但与正常对照者不同的是，患者的鞘磷脂和胆固醇比例似乎较低，而磷脂酰丝氨酸含量似乎较高，其增加量与测量值95%置信区间的总和相当。未检测到红细胞膜蛋白质组成有重大差异。
