Olivero W C, Dulebohn S C, Lister J R
Department of Neuroscience, University of Illinois College of Medicine at Peoria.
J Neurol Neurosurg Psychiatry. 1995 Feb;58(2):250-2. doi: 10.1136/jnnp.58.2.250.
During an 18 month period 39 patients were evaluated with [18F] fluorodeoxyglucose-PET (FDG-PET) for primary brain tumours. These included patients with suspected newly diagnosed tumours and patients with known tumours who were being evaluated for possible recurrence or increasing tumour grade. Scans were performed on a 951-31 Siemen's PET scanner with 4 mm resolution. Scanning time was about 20 minutes per patient. All patients had undergone recent cerebral MRI. These patients were divided into two groups. In the first group (30) MRI and PET concurred on the diagnosis. The second group (nine) comprised those where the interpretation of MRI and PET was different or there was a question of the diagnosis on MRI. This group comprised three patients in whom MRI suggested recurrent tumour and PET inaccurately suggested radiation necrosis; two patients with newly diagnosed enhancing lesions on MRI in whom PET was useful in distinguishing strokes from tumour; two patients with prior gliomas with new enhancing isolated lesions on MRI in whom PET scan accurately depicted radiation necrosis; and two patients with newly diagnosed enhancing lesions on MRI in whom PET scan was helpful in distinguishing multiple sclerosis from tumour in one but not in the other. Therefore, of the 39 patients, PET was helpful in five in distinguishing tumour from other disease processes; but, in so far as influencing treatment, it seemed helpful in only two. Thus PET seems to be of limited value as an aid to evaluating and treating patients with suspected or known primary brain tumours.
在18个月的时间里，对39例原发性脑肿瘤患者进行了[18F]氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）评估。这些患者包括疑似新诊断肿瘤的患者以及已知肿瘤且正在评估是否可能复发或肿瘤分级增加的患者。扫描使用的是分辨率为4毫米的951-31西门子PET扫描仪。每位患者的扫描时间约为20分钟。所有患者近期均接受过脑部MRI检查。这些患者被分为两组。第一组（30例）中，MRI和PET对诊断结果一致。第二组（9例）包括MRI和PET的解读不同或MRI诊断存在疑问的患者。该组包括3例患者，MRI提示肿瘤复发而PET错误地提示为放射性坏死；2例MRI显示新诊断的强化病变患者，PET有助于区分中风和肿瘤；2例既往患有胶质瘤且MRI显示新的孤立强化病变的患者，PET扫描准确显示为放射性坏死；以及2例MRI显示新诊断的强化病变患者，PET扫描在其中1例中有助于区分多发性硬化和肿瘤，而在另1例中则无帮助。因此，在这39例患者中，PET在5例患者中有助于区分肿瘤与其他疾病过程；但就影响治疗而言，似乎仅在2例中有所帮助。因此，PET作为评估和治疗疑似或已知原发性脑肿瘤患者的辅助手段，其价值似乎有限。
