Selvig K A
Department of Dental Research, University of Bergen School of Dentistry, Norway.
J Periodontol. 1994 Dec;65(12):1169-72. doi: 10.1902/jop.1994.65.12.1169.
Experimentation in animal models has created a basis for highly improved therapeutic procedures in reconstructive periodontal surgery. This symposium has discussed several animal models currently used; additional models have been described in recent literature. The presentations by Drs. Caton, Wikesjö, and Lynch illustrated the need for further discussion of some of the problems inherent in animal experimentation, including: standardization of periodontal defect configuration; adequate recording of preoperative attachment level; minimizing the effect of biological variability; use of surgically-created versus naturally-developed periodontal lesions; choice of observation period; and regenerative potential of the model chosen.
动物模型实验为重建性牙周手术中治疗程序的大幅改进奠定了基础。本次研讨会讨论了目前使用的几种动物模型；近期文献中还描述了其他模型。卡顿博士、维克舍博士和林奇博士的报告表明，有必要进一步讨论动物实验中存在的一些固有问题，包括：牙周缺损形态的标准化；术前附着水平的充分记录；将生物变异性的影响降至最低；使用手术造成的牙周病变与自然发生的牙周病变；观察期的选择；以及所选模型的再生潜力。
