Caton J, Mota L, Gandini L, Laskaris B
Department of Periodontology, Eastman Dental Center, Rochester, NY.
J Periodontol. 1994 Dec;65(12):1143-50. doi: 10.1902/jop.1994.65.12.1143.
Experimentally-produced defects in the non-human primate are preferred for testing the efficacy and safety of periodontal regenerative therapies. These animals closely resemble the human in dental anatomy and periodontal wound healing physiology. Defects can be produced which do not display spontaneous regeneration and which are contralaterally identical. Thus, within animals, untreated controls can be obtained to indicate the level of supporting tissues prior to therapy. The use of non-human primate models is recommended for science transfer experiments involving invasive surgery and the testing of potentially harmful new devices and pharmaceuticals.
在测试牙周再生疗法的疗效和安全性时，非人类灵长类动物身上通过实验制造的缺损是首选。这些动物在牙齿解剖结构和牙周伤口愈合生理方面与人类极为相似。可以制造出不会自发再生且双侧对称的缺损。这样，在动物体内就能获得未经治疗的对照，以表明治疗前支持组织的水平。对于涉及侵入性手术以及测试潜在有害的新设备和药物的科学转化实验，建议使用非人类灵长类动物模型。
