Werkmeister J A, White J F, Ramshaw J A
CSIRO, Division of Biomolecular Engineering, Parkville, Victoria, Australia.
Med Prog Technol. 1994;20(3-4):231-42.
The Omniflow Vascular Prosthesis (OVP) is a truly integrated bio-synthetic composite of polyester mesh and ovine connective tissue components. In animal and human studies, the prosthesis has demonstrated long-term patency rates comparable and often better than alternate surgical replacements, with minimal aneurysmal or thrombotic problems. Immunohistological and TEM analysis of explants of OVP I provide good evidence for the excellent in vivo performance and are reviewed below. In addition, new data from explants of the OVP II, a later version of the Omniflow, are also described. These explant analyses have been enhanced by use of a library of highly specific monoclonal antibodies which can discriminate between collagens from different species.
全流血管假体（OVP）是一种由聚酯网和羊结缔组织成分真正整合而成的生物合成复合材料。在动物和人体研究中，该假体已显示出长期通畅率与其他外科替代物相当，且常常优于其他替代物，动脉瘤或血栓形成问题极少。对OVP I植入物的免疫组织学和透射电镜分析为其在体内的优异性能提供了有力证据，如下所述。此外，还描述了全流血管假体后期版本OVP II植入物的新数据。通过使用一组高度特异性的单克隆抗体文库，这些植入物分析得到了加强，该文库能够区分不同物种的胶原蛋白。
