Hiob Matti A, Crouch Gareth W, Weiss Anthony S
School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia; Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.
Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.
Curr Opin Biotechnol. 2016 Aug;40:149-154. doi: 10.1016/j.copbio.2016.04.008. Epub 2016 May 2.
Elastomers are popular in vascular engineering applications, as they offer the ability to design implants that match the compliance of native tissue. By mimicking the natural tissue environment, elastic materials are able to integrate within the body to promote repair and avoid the adverse physiological responses seen in rigid alternatives that often disrupt tissue function. The design of elastomers has continued to evolve, moving from a focus on long term implants to temporary resorbable implants that support tissue regeneration. This has been achieved through designing chemistries and processing methodologies that control material behavior and bioactivity, while maintaining biocompatibility in vivo. Here we review the latest developments in synthetic and natural elastomers and their application in cardiovascular treatments.
弹性体在血管工程应用中很受欢迎，因为它们能够设计出与天然组织顺应性相匹配的植入物。通过模拟天然组织环境，弹性材料能够在体内整合以促进修复，并避免在刚性替代物中常见的往往会破坏组织功能的不良生理反应。弹性体的设计不断发展，从专注于长期植入物转向支持组织再生的临时可吸收植入物。这是通过设计控制材料行为和生物活性的化学方法和加工方法来实现的，同时在体内保持生物相容性。在此，我们综述合成和天然弹性体的最新进展及其在心血管治疗中的应用。
