• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

氯乙烯的遗传毒理学——综述

Genetic toxicology of vinyl chloride--a review.

作者信息

Giri A K

机构信息

Division of Toxicology, Central Drug Research Institute, Lucknow, India.

出版信息

Mutat Res. 1995 Feb;339(1):1-14. doi: 10.1016/0165-1110(94)00011-z.

DOI:10.1016/0165-1110(94)00011-z
PMID:7877642
Abstract

Vinyl chloride (VC) is a colorless gas with a mild, sweet odor. It is extensively used in the production of vinyl chloride polymer, copolymer resin, packaging materials, wire and cable coatings as well as in industrial and laboratory intermediates. It is toxic and also carcinogenic in experimental animals. The wide human exposure to this compound in different industries throughout the world causes great concern for human health. In the present review an attempt has been made to evaluate and update the genotoxic effects of vinyl chloride based on the available literature.

摘要

氯乙烯(VC)是一种无色气体,有轻微的甜味。它广泛用于生产氯乙烯聚合物、共聚物树脂、包装材料、电线和电缆涂层以及工业和实验室中间体。它有毒,在实验动物中也具有致癌性。全世界不同行业的人群广泛接触这种化合物,这引起了人们对人类健康的极大关注。在本综述中,已尝试根据现有文献评估和更新氯乙烯的遗传毒性作用。

相似文献

1
Genetic toxicology of vinyl chloride--a review.氯乙烯的遗传毒理学——综述
Mutat Res. 1995 Feb;339(1):1-14. doi: 10.1016/0165-1110(94)00011-z.
2
Mutagenicity of vinyl chloride in man: comparison of chromosome aberrations with micronucleus and sister-chromatid exchange frequencies.氯乙烯对人体的致突变性:染色体畸变与微核及姐妹染色单体交换频率的比较。
Mutat Res. 1990 Dec;242(4):265-70. doi: 10.1016/0165-1218(90)90044-3.
3
Vinyl chloride and vinyl benzene (styrene)--metabolism, mutagenicity and carcinogenicity.
Chem Biol Interact. 1978 Jul;22(1):117-24. doi: 10.1016/0009-2797(78)90155-2.
4
A comprehensive analysis of plausible genotoxic covariates among workers of a polyvinyl chloride plant exposed to vinyl chloride monomer.对暴露于氯乙烯单体的聚氯乙烯工厂工人中可能存在遗传毒性的协变量进行综合分析。
Arch Environ Contam Toxicol. 2013 May;64(4):652-8. doi: 10.1007/s00244-012-9857-1. Epub 2012 Dec 28.
5
Mutagenicity of vinyl chloride monomer.氯乙烯单体的致突变性。
Arch Belg Med Soc. 1977 Nov-Dec;35(9-10):585-600.
6
Vinyl chloride: an example for evaluating mutagenic effects in mammals in vivo after exposure to inhalation.氯乙烯:吸入暴露后评估哺乳动物体内诱变效应的一个实例。
Arch Toxicol. 1980 May;45(1):1-7. doi: 10.1007/BF00303288.
7
X-rays, microwaves and vinyl chloride monomer: their clastogenic and aneugenic activity, using the micronucleus assay on human lymphocytes.X射线、微波和氯乙烯单体:利用人类淋巴细胞微核试验检测它们的致断裂和致非整倍体活性。
Mutat Res. 1992 Aug;282(4):265-71. doi: 10.1016/0165-7992(92)90133-3.
8
Mutations in apoptotic genes and micronucleus occurrence in vinyl chloride-exposed workers in China.中国氯乙烯暴露工人凋亡基因的突变与微核发生情况
Environ Mol Mutagen. 2017 Jan;58(1):39-45. doi: 10.1002/em.22046. Epub 2016 Nov 1.
9
Mutagenicity of vinyl chloride. External chromosome studies on persons with and without VC illness, and on VC exposed animals.氯乙烯的致突变性。对患有和未患有氯乙烯疾病的人员以及接触氯乙烯的动物进行的外周染色体研究。
J Occup Med. 1978 Aug;20(8):557-61.
10
Vinyl chloride and acrylonitrile: activation mechanism and mutagenicity.
Toxicol Eur Res. 1982 Jan;4(1):35-7.

引用本文的文献

1
Evaluation of cell types for assessment of cytogenetic damage in arsenic exposed population.
Mol Cancer. 2008 May 28;7:45. doi: 10.1186/1476-4598-7-45.
2
Vinyl chloride: still a cause for concern.氯乙烯:仍然令人担忧。
Environ Health Perspect. 2000 Jul;108(7):579-88. doi: 10.1289/ehp.00108579.