Palva E S, Linnoila M, Mattila M J
Mod Probl Pharmacopsychiatry. 1976;11:79-84. doi: 10.1159/000399455.
The interaction of the main metabolites of diazepam and chlordiazepoxide with alcohol was measured in two double-blind crossover subacute experiments on 40 healthy young volunteers. The drugs were administered for 2 weeks each. The variables measured were choice reaction time and accuracy, eye-hand coordination, divided attention, flicker fusion, proprioception, and nystagmus. ChL, MO and O significantly enhanced the alcohol-induced impairment of psychomotor skills whereas DMD did so only exceptionally on some subjects in the choice reaction test. It is concluded that the diazepam-alcohol interaction on psychomotor skills is mainly due to the parent compound. No correlations between the serum levels of the agents and the changes of performance were found.
在针对40名健康年轻志愿者开展的两项双盲交叉亚急性实验中，测定了地西泮和氯氮卓主要代谢产物与酒精之间的相互作用。每种药物均给药2周。所测量的变量包括选择反应时间和准确性、眼手协调能力、注意力分散、闪光融合、本体感觉和眼球震颤。氯氮卓、去甲地西泮和奥沙西泮显著增强了酒精引起的精神运动技能损害，而地西泮葡糖醛酸在选择反应测试中仅在部分受试者身上有异常增强。得出的结论是，地西泮与酒精在精神运动技能方面的相互作用主要归因于母体化合物。未发现药物血清水平与行为变化之间存在相关性。
