Palva E S, Linnoila M
Eur J Clin Pharmacol. 1978 Jul 30;13(5):345-50. doi: 10.1007/BF00644607.
Interaction of the main metabolites of diazepam and chlordiazepoxide with alcohol was measured in two subacute double-blind cross-over experiments on 40 healthy, young volunteers. The drugs were administered for two week periods. The variables measured were choice reaction time and accuracy, eye-hand co-ordination, divided attention, flicker fusion, proprioception and nystagmus. Chlordiazepoxide lactam, methyloxazepam and oxazepam significantly enhanced the alcohol-induced impairment of psychomotor skills, whereas N-desmethyl-diazepam did so only exceptionally in certain subjects in the choice reaction test. It is concluded that diazepam-alcohol interaction on psychomotor skills is mainly due to the parent compound. No correlation between the serum level of the agents and the changes in performance were found.
在两项针对40名健康年轻志愿者的亚急性双盲交叉实验中，对安定和氯氮卓的主要代谢产物与酒精的相互作用进行了测定。药物给药为期两周。所测量的变量包括选择反应时间和准确性、眼手协调能力、分散注意力、闪光融合、本体感觉和眼球震颤。氯氮卓内酰胺、甲基奥沙西泮和奥沙西泮显著增强了酒精引起的精神运动技能损害，而N-去甲基安定仅在某些受试者的选择反应测试中偶尔出现这种情况。得出的结论是，安定与酒精在精神运动技能方面的相互作用主要归因于母体化合物。未发现药物血清水平与性能变化之间存在相关性。
