Kinetic and affinity limits on antibodies produced during immune responses.
作者信息
Foote J, Eisen H N
机构信息
Fred Hutchinson Cancer Research Center, University of Washington, Seattle 98104.
出版信息
Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1254-6. doi: 10.1073/pnas.92.5.1254.
Abstract
摘要
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Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1254-6. doi: 10.1073/pnas.92.5.1254.
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本文引用的文献
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VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE.免疫应答过程中抗体亲和力的变化
Biochemistry. 1964 Jul;3:996-1008. doi: 10.1021/bi00895a027.
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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.对（4-羟基-3-硝基苯基）乙酰基的初次免疫应答的原位研究。III. 生发中心B细胞中V区突变与选择的动力学
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Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.早期产生高亲和力的中和抗病毒IgG反应，但亲和力没有进一步全面提高。
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IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts.针对磷酸胆碱的IgG抗体比其对应的IgM抗体表现出更多样性。
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mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification.信使核糖核酸序列定义了对2-苯基恶唑酮异常受限的免疫球蛋白G反应及其早期多样化。
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Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region.重链可变区对NPb抗体家族的贡献：γ2a可变区中明显的体细胞突变。
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Expression of defined idiotypes throughout the BALB/c anti-fluorescyl antibody response: affinity and idiotype analyses of heterogeneous antibodies.BALB/c抗荧光素抗体应答过程中特定独特型的表达：异质性抗体的亲和力和独特型分析
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Antibody affinity. II. Effect of immunization interval on antihapten antibody in the rabbit.
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Variability in the lambda light chain sequences of mouse antibody.小鼠抗体λ轻链序列的变异性
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