Saito M, Broderick G A, Wein A J, Levin R M
Division of Urology, University of Pennsylvania, School of Medicine, Philadelphia.
Pharmacology. 1994 Dec;49(6):386-91. doi: 10.1159/000139257.
Previous studies demonstrated that acute in vitro exposure of corpus cavernosal tissue to ethanol decreased its response to field stimulation and pharmacological stimulation. In the current study the effects of chronic ethanol consumption on the responses of the rabbit corpus cavernosum to field stimulation and various autonomic agonists were investigated. Five percent (V/V) ethanol in drinking water was given to rabbits for 6 weeks. At the end of this time the in vitro response of the corpus cavernosum to various forms of stimulation was determined. The corporal smooth muscle taken from rabbits subjected to chronic ethanol consumption demonstrated the following characteristics compared to tissue taken from control rabbits. (1) Under basal conditions, both relaxation and contraction induced by field stimulation were significantly increased. (2) Contractions to both phenylephrine and KCl increased significantly. (3) In the tissue preincubated with phenylephrine, relaxations induced by field stimulation, ATP, and bethanechol were significantly enhanced. (4) The relaxation responses to sodium nitroprusside were not changed by chronic exposure to ethanol. These findings suggest that in vivo chronic ethanol administration augmented both stimulated contracation and stimulated relaxation of the corporal smooth muscle.
先前的研究表明，体外将阴茎海绵体组织急性暴露于乙醇会降低其对电场刺激和药理刺激的反应。在本研究中，研究了长期摄入乙醇对兔阴茎海绵体对电场刺激和各种自主神经激动剂反应的影响。给兔子饮用含5%（V/V）乙醇的水，持续6周。在这段时间结束时，测定阴茎海绵体对各种形式刺激的体外反应。与取自对照兔的组织相比，取自长期摄入乙醇的兔的海绵体平滑肌表现出以下特征。（1） 在基础条件下，电场刺激引起的舒张和收缩均显著增加。（2） 对去氧肾上腺素和氯化钾的收缩均显著增加。（3） 在预先用去氧肾上腺素孵育的组织中，电场刺激、ATP和氨甲酰甲胆碱引起的舒张显著增强。（4） 长期暴露于乙醇对硝普钠的舒张反应没有改变。这些发现表明，体内长期给予乙醇会增强海绵体平滑肌的刺激收缩和刺激舒张。
