Saijo N
Pharmacology Division, National Cancer Center Research Institute.
Gan To Kagaku Ryoho. 1995 Feb;22(3):371-81.
The purpose of the studies for drug resistance could be summarized in the following four points. 1) Mechanisms of acquired drug resistance can be translated to those of inherent resistance. 2) Molecular targets of anticancer drugs can be clarified and accurate application of methods for the overcoming of drug resistance may be possible. 3) Important hints can be obtained for the development of new anticancer agents against molecular targets. 4) Efficient methods can be provided to find new anticancer agents against drug refractory tumors. The clinical strategies for the overcoming of drug resistance are 1) the use of non cross-resistant drugs, 2) the application of the drugs for overcoming resistance, 3) high dose chemotherapy, and 4) the combined use of radiotherapy and surgery.
耐药性研究的目的可归纳为以下四点。1）获得性耐药机制可转化为固有耐药机制。2）可明确抗癌药物的分子靶点，并可能准确应用克服耐药性的方法。3）可为针对分子靶点开发新型抗癌药物提供重要线索。4）可为寻找针对难治性肿瘤的新型抗癌药物提供有效方法。克服耐药性的临床策略包括：1）使用非交叉耐药药物；2）应用克服耐药性的药物；3）大剂量化疗；4）放疗与手术联合使用。
