Chan T Y, Lui S F, Chung S Y, Luk S, Critchley J A
Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T.
Drug Saf. 1994 Mar;10(3):267-9. doi: 10.2165/00002018-199410030-00006.
A 57-year-old man developed spontaneous skin bruising and haematuria during combined therapy with warfarin and indomethacin. Due to the potential effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the anticoagulant action of warfarin and platelet function, patients receiving both warfarin and NSAIDs should have their prothrombin time monitored very closely. Also, the risk of gastrointestinal haemorrhage with any NSAIDs must always be remembered.
一名57岁男性在华法林与吲哚美辛联合治疗期间出现自发性皮肤瘀斑和血尿。由于非甾体抗炎药（NSAIDs）对华法林抗凝作用和血小板功能的潜在影响，同时接受华法林和NSAIDs治疗的患者应密切监测其凝血酶原时间。此外，必须始终牢记使用任何NSAIDs都有发生胃肠道出血的风险。
