Yip A S, Chow W H, Tai Y T, Cheung K L
Department of Medicine, Grantham Hospital, Aberdeen, Hong Kong.
Postgrad Med J. 1990 May;66(775):367-9. doi: 10.1136/pgmj.66.775.367.
The adverse effect of topical methylsalicylate ointment on warfarin anticoagulation is studied in 11 patients. All patients had an abnormally elevated international normalized ratio after significant usage of topical methylsalicylate ointment as obvious from both the clinical history and a positive blood level of salicylate. Out of the 11 patients, 3 had bleeding manifestation; 2 with bruises and 1 with gastrointestinal bleeding. It is concluded that topical methylsalicylate ointment should be prescribed with care to patients on warfarin and excessive usage is to be avoided since potentially dangerous drug interaction could occur.
对11例患者研究了外用水杨酸甲酯软膏对华法林抗凝作用的不良影响。从临床病史和水杨酸血药浓度阳性结果来看，所有患者在大量使用外用水杨酸甲酯软膏后国际标准化比值均异常升高。11例患者中，3例有出血表现，2例有瘀斑，1例有胃肠道出血。结论是，对华法林治疗的患者开具外用水杨酸甲酯软膏时应谨慎，应避免过量使用，因为可能会发生潜在危险的药物相互作用。
