Cassatella M A
Istituto di Patologia Generale, Università di Verona, Italy.
Immunol Today. 1995 Jan;16(1):21-6. doi: 10.1016/0167-5699(95)80066-2.
Cytokines orchestrate the complex network of cellular interactions that regulate effector cell functions of natural and immune resistance. Although T cells, natural killer (NK) cells and monocytes/macrophages are the main producers of cytokines, a number of reports in the last few years have demonstrated that polymorphonuclear neutrophils (PMN) also have the ability to synthesize and release immunoregulatory cytokines. Here, Marco Cassatella describes novel facets of the regulation of cytokine production by PMN that highlight the involvement of of PMN in cell-cytokine crosstalk.
细胞因子精心编排细胞间相互作用的复杂网络，这些相互作用调节天然免疫和免疫抵抗的效应细胞功能。虽然T细胞、自然杀伤（NK）细胞和单核细胞/巨噬细胞是细胞因子的主要产生者，但过去几年的一些报告表明，多形核中性粒细胞（PMN）也有合成和释放免疫调节细胞因子的能力。在此，马尔科·卡萨泰拉描述了PMN调节细胞因子产生的新方面，这些方面突出了PMN在细胞-细胞因子相互作用中的参与。
