阴道念珠菌病女性患者脱落的阴道上皮细胞中β-胡萝卜素水平降低。
Decreased beta-carotene levels in exfoliated vaginal epithelial cells in women with vaginal candidiasis.
作者信息
Mikhail M S, Palan P R, Basu J, Anyaegbunam A, Romney S L
机构信息
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, New York 10461.
出版信息
Am J Reprod Immunol. 1994 Oct;32(3):221-5. doi: 10.1111/j.1600-0897.1994.tb01117.x.
PROBLEM
Women are more susceptible to vaginal candidiasis when the host immune response is suppressed. The antioxidant nutrient beta-carotene is postulated to possess immunoenhancing properties. The purpose of this study was to investigate beta-carotene concentrations in exfoliated vaginal epithelial (EVE) cells in women with vaginal candidiasis.
METHODS
Beta-carotene levels in EVE cells, collected by a saline lavage technique from 22 women with vaginal candidiasis and 20 normal controls, were analyzed. The diagnosis of vaginal candidiasis was established by the presence of pruritus, white cheesy vaginal discharge, and a positive potassium hydroxide preparation. Beta-carotene levels were assayed using high pressure liquid chromatography.
RESULTS
Vaginal cell concentrations of beta-carotene were significantly decreased in women with vaginal candidiasis (P < 0.001).
CONCLUSIONS
Decreased beta-carotene levels, and possibly other antioxidants, may alter the local immune response resulting in disturbances in the vaginal flora, overgrowth of candida, and the development of vaginal candidiasis.
问题
当宿主免疫反应受到抑制时，女性更容易患阴道念珠菌病。抗氧化营养素β-胡萝卜素被认为具有免疫增强特性。本研究的目的是调查患有阴道念珠菌病的女性脱落阴道上皮（EVE）细胞中的β-胡萝卜素浓度。
方法
分析了通过盐水灌洗技术从22名患有阴道念珠菌病的女性和20名正常对照者收集的EVE细胞中的β-胡萝卜素水平。通过瘙痒、白色奶酪样阴道分泌物以及氢氧化钾制剂阳性来确诊阴道念珠菌病。使用高压液相色谱法测定β-胡萝卜素水平。
结果
患有阴道念珠菌病的女性阴道细胞中的β-胡萝卜素浓度显著降低（P < 0.001）。
结论
β-胡萝卜素水平降低以及可能的其他抗氧化剂可能会改变局部免疫反应，导致阴道菌群紊乱、念珠菌过度生长以及阴道念珠菌病的发生。
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