Lewis W G, Walker V A, Ali H H, Sainsbury J R
Department of Surgery, Huddersfield Royal Infirmary, UK.
Br J Cancer. 1995 Mar;71(3):605-9. doi: 10.1038/bjc.1995.117.
The aim of this study was to assess the practicality of treating patients with various stages of breast cancer by means of regional (intra-arterial) chemotherapy. Three groups of patients received a median of four (range 2-4) cycles of combination chemotherapy: group I operable primary (n = 10); group II, locally advanced disease (n = 20); group III, recurrent locoregional disease (n = 22). The response rates (complete response, partial response and mixed response) in these groups of patients were 100% in groups I and II and 86% in group III. Morbidity included drug streaming and dysaesthesia in the hand. Patients in groups I and II had their tumours downstaged, allowing surgery to be performed. Local control was also achieved in group III when other treatment modalities had failed.
本研究的目的是评估通过区域（动脉内）化疗治疗不同阶段乳腺癌患者的实用性。三组患者接受了中位数为四个（范围2 - 4个）周期的联合化疗：第一组为可手术的原发性乳腺癌患者（n = 10）；第二组为局部晚期疾病患者（n = 20）；第三组为局部区域复发性疾病患者（n = 22）。这些组患者的缓解率（完全缓解、部分缓解和混合缓解）在第一组和第二组中为100%，在第三组中为86%。并发症包括药物外渗和手部感觉异常。第一组和第二组患者的肿瘤分期降低，从而能够进行手术。当其他治疗方式失败时，第三组也实现了局部控制。
