Guerzoni M E, Del Cupolo L
S TA NU. 1976 May-Jun;6(3):161-5.
The mutagenicity of sixty pesticides was investigated in three strains of Saccharomyces cerevisiae using reversion from histidine and methionine auxotrophy as a measure of the induced mutation. Mutagenesis was observed in twenty three compounds; the strains employed exhibit different susceptibility to the mutagenic action. In view of the data obtained the possible mechanisms of action of the different class of compounds are discussed.
使用从组氨酸和蛋氨酸营养缺陷型回复突变作为诱导突变的指标,在三株酿酒酵母中研究了60种农药的致突变性。在23种化合物中观察到了诱变作用;所使用的菌株对诱变作用表现出不同的敏感性。根据所获得的数据,讨论了不同类别化合物可能的作用机制。