Faury G, Ristori M T, Verdetti J, Jacob M P, Robert L
Centre de Physiologie Cellulaires, Université Joseph Fourier, Grenoble, France.
C R Acad Sci III. 1994 Sep;317(9):807-11.
The elastin-laminin receptor was shown to be present on several benign and malignant cell types and to mediate several important cell reactions such as chemotactic movements of fibroblasts and monocytes, release of lytic enzymes and oxygen free radicals from leucocytes, increased adhesion of mesenchymal cells to elastin fibers as well as modifications of ion fluxes-increase of calcium and sodium influxes and decrease of ouabain-dependent potassium influx. We now demonstrated that the addition of elastin peptides to rat aorta rings precontracted with noradrenaline produced an endothelium-dependent vasorelaxation. The inhibition of this effect by laminin and lactose is in favor of the mediation of this action of elastin peptides by the 67 kDa subunit of the elastin-laminin receptor which possesses a lectin site. As elastin peptides are present in the circulating blood and their concentration was shown to increase in some pathological conditions, this phenomenon may well have physiopathological significance.
弹性蛋白-层粘连蛋白受体已被证明存在于多种良性和恶性细胞类型上，并介导多种重要的细胞反应，如成纤维细胞和单核细胞的趋化运动、白细胞释放溶解酶和氧自由基、间充质细胞与弹性纤维的粘附增加以及离子通量的改变——钙和钠内流增加以及哇巴因依赖性钾内流减少。我们现在证明，向用去甲肾上腺素预收缩的大鼠主动脉环中添加弹性蛋白肽会产生内皮依赖性血管舒张。层粘连蛋白和乳糖对这种作用的抑制有利于弹性蛋白肽的这种作用由具有凝集素位点的弹性蛋白-层粘连蛋白受体的67 kDa亚基介导。由于弹性蛋白肽存在于循环血液中，并且其浓度在某些病理状态下会升高，这种现象很可能具有生理病理学意义。
