Péterszegi G, Robert A M, Robert L
Laboratoire de biologie cellulaire, Université Paris VII, France.
C R Acad Sci III. 1996 Sep;319(9):799-803.
A variety of cells - fibroblasts, vascular smooth muscle cells, endothelial cells, monocytes and polymorphonuclear leukocytes (PMNs) - carry the elastin-laminin receptor. The activation of this receptor by elastin peptides triggers a variety of reactions as chemotactic movements to an elastin peptide gradient, release of lytic enzymes and oxygen-free radicals, modifications of ion fluxes. We now show that human lymphocytes also express this receptor. Membrane labelling of the receptor by specific antibodies shows capping. In the presence of elastin peptides lymphocytes show increased proliferation and increased production of an elastase type serine protease apparently identical to PMN-elastase, inhibited by cycloheximide and by anti-PMN elastase antibodies. T-lymphocytes are present in atherosclerotic plaques where elastin degradation occurs and could contribute to the chronicity of the lesion by the above mechanism.
多种细胞——成纤维细胞、血管平滑肌细胞、内皮细胞、单核细胞和多形核白细胞（PMN）——携带弹性蛋白-层粘连蛋白受体。弹性蛋白肽激活该受体可引发多种反应，如向弹性蛋白肽梯度的趋化运动、溶酶体酶和氧自由基的释放、离子通量的改变。我们现在表明，人类淋巴细胞也表达这种受体。用特异性抗体对受体进行膜标记显示有帽化现象。在弹性蛋白肽存在的情况下，淋巴细胞显示出增殖增加以及一种弹性蛋白酶型丝氨酸蛋白酶的产生增加，这种酶显然与PMN弹性蛋白酶相同，可被环己酰亚胺和抗PMN弹性蛋白酶抗体抑制。T淋巴细胞存在于发生弹性蛋白降解的动脉粥样硬化斑块中，并可能通过上述机制导致病变的慢性化。
