McPartland R J, Kupfer D J
Electroencephalogr Clin Neurophysiol. 1978 Aug;45(2):178-85. doi: 10.1016/0013-4694(78)90002-0.
The phase of the REM sleep rhythm was studied in 10 normal subjects each of whom was sleep studied for 4 consecutive nights. For analysis, each night of sleep was aligned according to clock time and each minute was scored as REM or non-REM. With these data, REM probability was found as a function of clock time. Fractional harmonic analysis indicates a 90 min periodicity. The REM probability curve shows peaks occurring at 1:30 a.m., 3:15 a.m., 4:30 a.m., 5:45 a.m. and 7:00 a.m. Statistical measures comparing the time of REM sleep across subjects suggests that subjects tend to have REM sleep at the same time of the night as each other. The influence of elapsed time after sleep onset on REM sleep is also reestablished. Results indicate that the time of REM sleep is determined by both clock time and time of sleep onset, suggesting two clocks, one sleep dependent and the other related to the basic rest activity cycle (BRAC), which are responsible for driving REM sleep. Furthermore, the similarity of REM times across subjects indicates the possible existence of an extra-personae REM driving force linked to clock time and possibly the BRAC.
对10名正常受试者的快速眼动（REM）睡眠节律阶段进行了研究，每位受试者连续4个晚上接受睡眠监测。为了进行分析，每晚的睡眠根据时钟时间进行校准，每分钟被标记为REM或非REM。利用这些数据，发现REM概率是时钟时间的函数。分数谐波分析表明存在90分钟的周期性。REM概率曲线显示在凌晨1:30、3:15、4:30、5:45和7:00出现峰值。比较不同受试者REM睡眠时间的统计方法表明，受试者往往在夜间的同一时间进入REM睡眠。睡眠开始后经过的时间对REM睡眠的影响也得到了重新确认。结果表明，REM睡眠的时间由时钟时间和睡眠开始时间共同决定，这表明存在两个时钟，一个依赖于睡眠，另一个与基本休息活动周期（BRAC）有关，它们共同驱动REM睡眠。此外，不同受试者REM时间的相似性表明可能存在一种与时钟时间以及可能与BRAC相关的额外的个体REM驱动力。
