Petersen H, Berstad A, Myren J
Acta Hepatogastroenterol (Stuttg). 1976 Jul-Aug;23(4):288-91.
Five healthy subjects received on one occasion 2 mug/kg-hour of pentagastrin alone and on another occasion in combination with synthetic secretin (Schwarz/Mann) in the dose of 2 U/kg-hour. The gastric and duodenal contents were collected continuously through a gastroduodenal Lagerlöf tube. Polyethylene glycol and 57Co labelled vitamin B12 were used as non absorbable markers in the duodenum and in the stomach, respectively. In each subject synthetic secretin inhibited acid (mean inhibition 17 percent) and stimulated pepsin secretin (mean stimulation 49 percent). The findings indicate that these actions are properties of secretin itself.
五名健康受试者，一次单独接受2微克/千克·小时的五肽胃泌素，另一次接受2单位/千克·小时剂量的合成促胰液素（施瓦茨/曼恩公司）与五肽胃泌素联合使用。通过胃十二指肠拉格洛夫管持续收集胃和十二指肠内容物。聚乙二醇和57钴标记的维生素B12分别用作十二指肠和胃中的不可吸收标记物。在每个受试者中，合成促胰液素抑制胃酸分泌（平均抑制率17%）并刺激胃蛋白酶分泌（平均刺激率49%）。这些发现表明这些作用是促胰液素本身的特性。
