Vatn M H, Myren J
Scand J Gastroenterol. 1976;11(4):421-5.
In 6 healthy students, the gastric secretion of acid, pepsin, and IF was measured during one hour at basal conditions, and during one hour of stimulation with 0.01 mug/kg/h and thereafter during one hour of stimulation with 0.1 mug/kg/h of pentagastrin. On separate days the same dose of pentagastrin was given in combination with 0.15 mug/kg/h or 1.5 mug/kg/h of carbachol, or stimulation was performed with each of the two doses of carbachol alone. A dose-dependent relationship was found between carbachol and the output of acid, pepsin, and IF. The responses to carbachol were independent of changes in plasma gastrin concentration. The acid- and IF-secretions stimulated by the largest dose of pentagastrin were significantly increased by the largest dose of carbachol, whereas the secretion of pepsin was not. Pentagastrin and carbachol seem to interact by competitive augmentation on the gastric secretion of acid and IF.
在6名健康学生中，于基础状态下测量了1小时的胃酸、胃蛋白酶和内因子分泌量，然后用0.01微克/千克/小时刺激1小时，之后用0.1微克/千克/小时的五肽胃泌素刺激1小时。在不同日期，给予相同剂量的五肽胃泌素，并分别联合0.15微克/千克/小时或1.5微克/千克/小时的卡巴胆碱，或者单独用两种剂量的卡巴胆碱进行刺激。发现卡巴胆碱与胃酸、胃蛋白酶和内因子的分泌量之间存在剂量依赖性关系。对卡巴胆碱的反应与血浆胃泌素浓度的变化无关。最大剂量的五肽胃泌素刺激的胃酸和内因子分泌量，在给予最大剂量的卡巴胆碱后显著增加，而胃蛋白酶的分泌量未增加。五肽胃泌素和卡巴胆碱似乎通过竞争性增强作用，影响胃酸和内因子的胃分泌。
