颗粒状蜕膜腺细胞：关于小鼠妊娠期可能功能的假说

Granulated metrial gland cells: hypotheses concerning possible functions during murine gestation.

作者信息

Croy B A

机构信息

Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada.

出版信息

J Reprod Immunol. 1994 Oct;27(2):85-94. doi: 10.1016/0165-0378(94)90025-6.

DOI:10.1016/0165-0378(94)90025-6

PMID:7884744

Abstract

Granulated metrial gland (GMG) cells are morphologically distinctive lymphoid cells found in the murine uterus only during gestation. The life history of GMG cells suggests that they have important roles during mammalian gestation but these roles have been difficult to define. Genetic and immunologic data suggest that GMG cells may be a specialized subset of natural killer (NK) lymphocytes. This has directed research on GMG cell functions towards questions of effector cell-target cell interactions. A broader range of potential functions is discussed and shifts in functional roles played by GMG cells are proposed over the course of gestation.

摘要

颗粒化子宫内膜腺（GMG）细胞是一种形态独特的淋巴细胞，仅在妊娠期的小鼠子宫中发现。GMG细胞的生命历程表明它们在哺乳动物妊娠期间发挥着重要作用，但这些作用一直难以确定。遗传学和免疫学数据表明，GMG细胞可能是自然杀伤（NK）淋巴细胞的一个特殊亚群。这使得对GMG细胞功能的研究转向效应细胞与靶细胞相互作用的问题。本文讨论了更广泛的潜在功能，并提出了GMG细胞在妊娠过程中功能作用的转变。