Heller D S, Moomjy M, Koulos J, Smith D
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York.
J Reprod Med. 1994 Dec;39(12):945-8.
Melanoma of the vulva is uncommon, and melanoma of the vagina is rare. The overall prognosis is poor and worse than for cutaneous melanomas. This appears to relate to diagnosis of genital lesions at an advanced stage. In a 28-year, retrospective analysis at Columbia Presbyterian Medical Center, there were 10 cases of primary melanoma of the lower genital tract. Seven cases of vulvar melanoma and three cases of vaginal melanoma were reviewed. All cases were in elderly women, and all were diagnosed at an advanced stage. The outcome in general was poor, regardless of therapy. This condition must be recognized earlier to afford an optimal patient outcome. Elderly women must undergo regular gynecologic care, and suspicious pigmented lesions must be biopsied.
外阴黑色素瘤并不常见，阴道黑色素瘤则更为罕见。总体预后较差，比皮肤黑色素瘤更糟。这似乎与生殖器病变在晚期才被诊断有关。在哥伦比亚长老会医学中心进行的一项为期28年的回顾性分析中，有10例下生殖道原发性黑色素瘤病例。对7例外阴黑色素瘤和3例阴道黑色素瘤进行了回顾。所有病例均为老年女性，且均在晚期被诊断出来。总体而言，无论接受何种治疗，结果都很差。必须更早地认识到这种情况，以便为患者提供最佳预后。老年女性必须接受定期妇科检查，对可疑的色素沉着病变必须进行活检。
