Rompelberg C J, Stenhuis W H, de Vogel N, van Osenbruggen W A, Schouten A, Verhagen H
TNO Nutrition and Food Research Institute, AJ Zeist, The Netherlands.
Mutat Res. 1995 Feb;346(2):69-75. doi: 10.1016/0165-7992(95)90053-5.
The antimutagenic effect of eugenol on the mutagenicity of cyclophosphamide (CP), mitomycin C (MMC), ethyl methanesulfonate (EMS) and benzo[a]pyrene (B[a]P) was assessed in the rodent bone marrow micronucleus test using male Swiss mice. Oral administration of eugenol (0.4% in the diet) for 15 days was found to decrease significantly the frequency of micronucleated polychromatic erythrocytes (MPEs) elevated by CP. No effect was found on the frequency of MPEs elevated by MMC, EMS and B[a]P. The results provide some support for antimutagenic potency of eugenol in vivo.
使用雄性瑞士小鼠，通过啮齿动物骨髓微核试验评估了丁香酚对环磷酰胺（CP）、丝裂霉素C（MMC）、甲磺酸乙酯（EMS）和苯并[a]芘（B[a]P）致突变性的抗诱变作用。发现口服丁香酚（饲料中含0.4%）15天可显著降低由CP引起的微核多染红细胞（MPEs）频率。未发现对由MMC、EMS和B[a]P引起的MPEs频率有影响。这些结果为丁香酚在体内的抗诱变效力提供了一些支持。
