Vijayalaxmi K K, Venu R
Department of Applied Zoology, Mangalore University, Mangalagangothri, 574 199 DK, India.
Mutat Res. 1999 Jan 2;438(1):47-51. doi: 10.1016/s1383-5718(98)00161-2.
The effects of l-ascorbic acid on the frequency of micronuclei induced by model mutagens, cyclophosphamide (CP), mitomycin-C (MMC) and bleomycin (BLM) hydrochloride were tested using mouse bone marrow. Three doses of ascorbic acid (AsA) viz., 10, 30 and 60 mg/kg b.w. were tested for anticlastogenic effects. The doses of positive mutagens used were, CP-50 mg/kg, MMC-4 mg/kg and BLM-20 mg/kg b.w. Bone marrow sampling was done at 24 h after the treatment. AsA was found to be effective in reducing MN frequency induced by CP and BLM. With MMC only, the highest dose showed a slight inhibitory effect.
利用小鼠骨髓检测了L-抗坏血酸对模型诱变剂环磷酰胺（CP）、丝裂霉素-C（MMC）和盐酸博来霉素（BLM）诱导的微核频率的影响。测试了三种剂量的抗坏血酸（AsA），即10、30和60毫克/千克体重，以检测其抗断裂效应。所用阳性诱变剂的剂量为，CP-50毫克/千克、MMC-4毫克/千克和BLM-20毫克/千克体重。处理后24小时进行骨髓取样。发现AsA可有效降低CP和BLM诱导的微核频率。仅对于MMC，最高剂量显示出轻微的抑制作用。
