Weil M L, Imagawa D T
Arch Virol. 1976;51(3):217-25. doi: 10.1007/BF01318025.
HeLa cells are non-permissive for the neurotropic suckling mouse strain of measles virus (MMV), but are permissive for cell-adapted Edmonston strain of measles virus (EDm). Fluorescence and electron microscopy demonstrated no membrane fluorescence and no membrane associated viral components, as well as characteristic lack of nuclear antigen after MMV infection of HeLa cells. This appearance differs markedly from the membrane, cytoplasmic and nuclear fluorescence after Edm infection of HeLa cells. Fluorescence microscopy demonstrates fusion of the two dissimilar syncytia after mixed infection. This suggests Edm envelopment of MMV nucleocapsids may be the means of MMV rescue in this system.
HeLa细胞对嗜神经性麻疹病毒乳鼠株（MMV）不敏感，但对细胞适应的麻疹病毒埃德蒙斯顿株（EDm）敏感。荧光显微镜和电子显微镜检查显示，MMV感染HeLa细胞后，无膜荧光、无膜相关病毒成分，且缺乏特征性的核抗原。这种现象与HeLa细胞受Edm感染后的膜、细胞质和核荧光明显不同。荧光显微镜显示混合感染后两种不同的多核巨细胞发生融合。这表明在该系统中，Edm对MMV核衣壳的包裹可能是MMV拯救的方式。
