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Transgenic models of retinoblastoma: what they tell us about its cause and treatment.

作者信息

Albert D M, Griep A E, Lambert P F, Howes K A, Windle J J, Lasudry J G

机构信息

Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison.

出版信息

Trans Am Ophthalmol Soc. 1994;92:385-400; discussion 400-1.

PMID:7886874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1298518/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/7e779901ecde/taos00007-0413-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/53f89f8a678f/taos00007-0407-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/01f4c85955f8/taos00007-0409-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/180d33ed59a2/taos00007-0411-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/5531d862ffaf/taos00007-0411-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/d655aa7f2e68/taos00007-0411-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/8feef55159ab/taos00007-0412-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/01039c1ad074/taos00007-0412-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/d24b8688560e/taos00007-0412-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/e7406d2a372d/taos00007-0412-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/7e779901ecde/taos00007-0413-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/53f89f8a678f/taos00007-0407-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/01f4c85955f8/taos00007-0409-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/180d33ed59a2/taos00007-0411-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/5531d862ffaf/taos00007-0411-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/d655aa7f2e68/taos00007-0411-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/8feef55159ab/taos00007-0412-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/01039c1ad074/taos00007-0412-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/d24b8688560e/taos00007-0412-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/e7406d2a372d/taos00007-0412-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdf/1298518/7e779901ecde/taos00007-0413-a.jpg

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Transgenic models of retinoblastoma: what they tell us about its cause and treatment.视网膜母细胞瘤的转基因模型：它们告诉我们的关于其病因及治疗的信息。
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引用本文的文献

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Penetration of Carbon Nanotubes into the Retinoblastoma Tumor after Intravitreal Injection in LH T Transgenic Mice Reti-noblastoma Model.在LH T转基因小鼠视网膜母细胞瘤模型中玻璃体内注射后碳纳米管对视网膜母细胞瘤肿瘤的穿透情况。
J Ophthalmic Vis Res. 2020 Oct 25;15(4):446-452. doi: 10.18502/jovr.v15i4.7778. eCollection 2020 Oct-Dec.
2
Transgenic Models in Retinoblastoma Research.视网膜母细胞瘤研究中的转基因模型
Ocul Oncol Pathol. 2015 Apr;1(3):207-13. doi: 10.1159/000370157. Epub 2015 Apr 9.
3
Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma.

本文引用的文献

1
Thymocyte apoptosis induced by p53-dependent and independent pathways.由p53依赖和非依赖途径诱导的胸腺细胞凋亡。
Nature. 1993 Apr 29;362(6423):849-52. doi: 10.1038/362849a0.
2
p53 is required for radiation-induced apoptosis in mouse thymocytes.p53是小鼠胸腺细胞辐射诱导凋亡所必需的。
Nature. 1993 Apr 29;362(6423):847-9. doi: 10.1038/362847a0.
3
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.p53 依赖性凋亡调节抗癌药物的细胞毒性。
用于治疗视网膜母细胞瘤的小分子疗法的进展
Mini Rev Med Chem. 2016;16(6):430-54. doi: 10.2174/1389557515666150722100610.
4
Lack of effect of SU1498, an inhibitor of vascular endothelial growth factor receptor-2, in a transgenic murine model of retinoblastoma.血管内皮生长因子受体-2抑制剂SU1498在视网膜母细胞瘤转基因小鼠模型中无效。
Open Ophthalmol J. 2008 Apr 2;2:62-7. doi: 10.2174/1874364100802010062.
5
Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells.细胞周期蛋白D1精细调节胚胎视网膜祖细胞的神经发生输出。
Neural Dev. 2009 May 5;4:15. doi: 10.1186/1749-8104-4-15.
6
Metastatic and nonmetastatic models of retinoblastoma.视网膜母细胞瘤的转移和非转移模型
Am J Pathol. 2000 Oct;157(4):1405-12. doi: 10.1016/S0002-9440(10)64653-6.
7
Multiple changes in oncogenes and tumor suppressor genes in human retinoblastoma.人类视网膜母细胞瘤中癌基因和肿瘤抑制基因的多种变化。
Trans Am Ophthalmol Soc. 1996;94:299-312; discussion 312-4.
Cell. 1993 Sep 24;74(6):957-67. doi: 10.1016/0092-8674(93)90719-7.
4
Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice.与人乳头瘤病毒16型E6和E7致癌基因在转基因小鼠皮肤中表达相关的表皮癌
Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5583-7. doi: 10.1073/pnas.90.12.5583.
5
Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation.人乳头瘤病毒16型E6和E7在转基因小鼠中的致瘤性与上皮细胞生长和分化的改变相关。
J Virol. 1993 Mar;67(3):1373-84. doi: 10.1128/JVI.67.3.1373-1384.1993.
6
Speculations on the roles of RB1 in tissue-specific differentiation, tumor initiation, and tumor progression.关于RB1在组织特异性分化、肿瘤起始和肿瘤进展中作用的推测。
FASEB J. 1993 Jul;7(10):846-54. doi: 10.1096/fasebj.7.10.8344484.
7
The genetics of retinoblastoma, revisited.视网膜母细胞瘤的遗传学，再探讨。
Am J Hum Genet. 1994 Feb;54(2):264-73.
8
Photoreceptor cell tumors in transgenic mice.转基因小鼠中的光感受器细胞瘤
Invest Ophthalmol Vis Sci. 1994 Feb;35(2):342-51.
9
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.凋亡或视网膜母细胞瘤：在有或无p53的情况下，表达人乳头瘤病毒16型E7基因的光感受器的不同命运。
Genes Dev. 1994 Jun 1;8(11):1300-10. doi: 10.1101/gad.8.11.1300.
10
Expression and amplification of the N-myc gene in primary retinoblastoma.N-myc基因在原发性视网膜母细胞瘤中的表达与扩增
Nature. 1984;309(5967):458-60. doi: 10.1038/309458a0.