人类视网膜母细胞瘤中癌基因和肿瘤抑制基因的多种变化。
Multiple changes in oncogenes and tumor suppressor genes in human retinoblastoma.
作者信息
Howard R O
机构信息
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
Trans Am Ophthalmol Soc. 1996;94:299-312; discussion 312-4.
Abstract
PURPOSE
To present data to support the hypothesis that human retinoblastoma tumors form by a multistep process.
METHODS
Survey of the karyotype of 90 human retinoblastomas, with emphasis on changes in chromosomal regions known to contain oncogenes and tumor suppressor genes.
CONCLUSION
The data support the hypothesis that retinoblastoma occurs after multiple and often varied steps, similar to other human malignancies.
摘要
目的
提供数据以支持人类视网膜母细胞瘤肿瘤通过多步骤过程形成的假说。
方法
对90例人类视网膜母细胞瘤的核型进行研究，重点关注已知含有癌基因和肿瘤抑制基因的染色体区域的变化。
结论
数据支持视网膜母细胞瘤与其他人类恶性肿瘤相似，在经历多个且通常各不相同的步骤后发生这一假说。
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