Marana R, Paielli F V, Muzii L, Dell'Acqua S, Mancuso S
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
Acta Eur Fertil. 1994 Jan-Feb;25(1):37-41.
The aim of the present study is to compare the outcome of GnRH analog treatment versus expectant management in infertile patients with minimal and mild endometriosis. From January 1987 to December 1990, 14 patients with stage I and II endometriosis underwent a six-month course of the GnRH analog buserelin, whereas 38 patients underwent expectant management. The two groups were comparable as to mean age of the patients, mean length of infertility prior to diagnosis and mean scores of endometriosis. No major tubal or male factor of infertility was present in any patient. Cumulative pregnancy rates at 12 months were comparable in the two groups (48% for GnRH analog treatment and 42% for expectant management). Expectant management should therefore be considered the most cost-effective option in the management of mild endometriosis-associated infertility.
本研究的目的是比较GnRH类似物治疗与期待治疗对轻度和中度子宫内膜异位症不孕患者的疗效。1987年1月至1990年12月，14例I期和II期子宫内膜异位症患者接受了为期6个月的GnRH类似物布舍瑞林治疗，而38例患者接受了期待治疗。两组患者的平均年龄、诊断前平均不孕时间和子宫内膜异位症平均评分具有可比性。所有患者均无主要输卵管或男性不孕因素。两组12个月时的累积妊娠率相当（GnRH类似物治疗组为48%，期待治疗组为42%）。因此，在轻度子宫内膜异位症相关性不孕的治疗中，期待治疗应被视为最具成本效益的选择。
