Tóth E, Remes P
Aeromedical Research Institute, Kecskemét, Hungary.
Acta Physiol Hung. 1994;82(2):125-30.
The effects of experimental copper deficiency by itself, and in combination with other factor resulting in ischaemic heart diseases (IHD), were investigated on the lipid composition and copper status of serum and aortic wall in rat. The depletion of absorbed copper was raised by complex formation (D-penicillamine-treatment). This provoked secondary copper deficiency was combined with a dietary cholesterol- and stress-loading. After treatment the levels of triglyceride (Tg), total cholesterol (Chol), HDL-cholesterol (HDL) (HDL = high density lipoprotein) and HDL2-cholesterol (HDL2) as well as copper (Cu) and zinc (Zn) in the serum and in aortic wall were measured by chemical analysis. It was pointed out, that increase in triglyceride and total cholesterol levels were promoted by the provoked copper deficiency in the serum and in the wall of the thoracic aorta. In combination with other risk factors it caused an increase in the elevation of Tg and Chol concentrations and has reduced the level of HDL2, significantly.
研究了实验性单纯铜缺乏以及与导致缺血性心脏病（IHD）的其他因素共同作用时，对大鼠血清和主动脉壁脂质组成及铜状态的影响。通过形成络合物（D-青霉胺处理）来增加吸收铜的耗竭。这种引发的继发性铜缺乏与饮食中胆固醇负荷和应激相结合。处理后，通过化学分析测量血清和主动脉壁中甘油三酯（Tg）、总胆固醇（Chol）、高密度脂蛋白胆固醇（HDL）（HDL = 高密度脂蛋白）和高密度脂蛋白2胆固醇（HDL2）以及铜（Cu）和锌（Zn）的水平。结果表明，血清和胸主动脉壁中引发的铜缺乏促进了甘油三酯和总胆固醇水平的升高。与其他危险因素共同作用时，它导致Tg和Chol浓度升高，并显著降低了HDL2水平。
