Coady T J, Stewart C J, Davis H J
Br J Clin Pharmacol. 1976 Apr;3(2):239-42. doi: 10.1111/j.1365-2125.1976.tb00598.x.
Saline and salbutamol (250 mug, 500 mug, 750 mug, and 1000 mug) injections were administered under double-blind conditions to seven chronic stable asthmatic patients. The response on the respiratory system (FEV1, FVC) and cardiovascular system (pulse rate, blood pressure and ECG) was monitored for 3 hours. Increasing the dose of salbutamol increased the peak and weighted average effects of FEV1 and pulse rate. The optimum dose, a titration of desired increases in FEV1 and undesirable increases in pulse rate, is 500 mug but doses up to 1000 mug may be administered if necessary.
在双盲条件下，对7名慢性稳定期哮喘患者注射生理盐水和沙丁胺醇（250微克、500微克、750微克和1000微克）。对呼吸系统（第一秒用力呼气量、用力肺活量）和心血管系统（脉搏率、血压和心电图）的反应进行了3小时的监测。增加沙丁胺醇剂量可提高第一秒用力呼气量和脉搏率的峰值及加权平均效应。最佳剂量是在期望的第一秒用力呼气量增加和不期望的脉搏率增加之间进行滴定，为500微克，但如有必要，剂量可高达1000微克。
