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1
How double blind is double blind? And does it matter?双盲究竟有多“双盲”?这重要吗?
Br J Clin Pharmacol. 1976 Apr;3(2):331-2. doi: 10.1111/j.1365-2125.1976.tb00612.x.
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Drug trial in rheumatoid arthritis: a new design.类风湿性关节炎药物试验:一种新设计。
Clin Pharmacol Ther. 1978 Feb;23(2):233-40. doi: 10.1002/cpt1978232233.
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[The course of patients treated with placebo in trials of maintenance treatment of rheumatoid arthritis. Consequences for phase II studies].
Rev Rhum Mal Osteoartic. 1990 Feb;57(2):119-22.
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Aspirin in rheumatoid arthritis, a seven-day, double-blind trial--preliminary report.阿司匹林治疗类风湿性关节炎的七天双盲试验——初步报告。
Bull Rheum Dis. 1965 Nov;16(3):388-91.
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[Clinical study on a new acetylsalicylic acid/paracetamol preparation with gastric acid resistant coating (Safapryn), and on two various phenylbutazone dosages in patients with primary chronic polyarthritis as based on a new evaluation method].
Z Rheumatol. 1975 Sep-Oct;34(9-10):350-65.
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A double-blind cross-over evaluation of ketoprofen and aspirin in rheumatoid arthritis.酮洛芬与阿司匹林治疗类风湿性关节炎的双盲交叉评估
Scand J Rheumatol Suppl. 1976;1976(0):99-104.
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[Clinical evaluation of drug efficacy by the double blind method in medicine (author's transl)].
Nihon Naika Gakkai Zasshi. 1976 Jan;65(1):15-29.
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Clinical experience with naproxen in rheumatoid arthritis.萘普生治疗类风湿性关节炎的临床经验。
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Bumadizone calcium in the treatment of rheumatoid arthritis.布马地宗钙治疗类风湿关节炎
S Afr Med J. 1977 Aug 27;52(10):391-3.
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Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin.用非诺洛芬治疗类风湿性关节炎:与阿司匹林的比较。
Br Med J. 1974 Feb 2;1(5900):176-80. doi: 10.1136/bmj.1.5900.176.

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Establishing mild, moderate, and severe scores for cancer-related symptoms: how consistent and clinically meaningful are interference-based severity cut-points?建立癌症相关症状的轻度、中度和重度评分:基于干扰的严重程度切点的一致性和临床意义如何?
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Quality of reports of clinical trials submitted by the drug industry to the Finnish and Swedish control authorities.制药行业提交给芬兰和瑞典监管机构的临床试验报告质量。
Eur J Clin Pharmacol. 1981 Feb;19(3):157-65. doi: 10.1007/BF00561942.

本文引用的文献

1
Placebos in the treatment of rheumatoid arthritis and other rheumatic conditions.安慰剂在类风湿关节炎及其他风湿性疾病治疗中的应用
Ann Rheum Dis. 1957 Mar;16(1):18-22. doi: 10.1136/ard.16.1.18.
2
Comparison of azathioprine, cyclophosphamide, and gold in treatment of rheumatoid arthritis.硫唑嘌呤、环磷酰胺和金制剂治疗类风湿关节炎的比较。
Br Med J. 1974 Sep 28;3(5934):763-6. doi: 10.1136/bmj.3.5934.763.
3
Simple analgesics for arthritis.用于关节炎的简单镇痛药。
Br Med J. 1974 Oct 26;4(5938):196-200. doi: 10.1136/bmj.4.5938.196.

双盲究竟有多“双盲”?这重要吗?

How double blind is double blind? And does it matter?

作者信息

Huskisson E C, Scott J

出版信息

Br J Clin Pharmacol. 1976 Apr;3(2):331-2. doi: 10.1111/j.1365-2125.1976.tb00612.x.

DOI:10.1111/j.1365-2125.1976.tb00612.x
PMID:788748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1428878/
Abstract

In an apparently double blind crossover study, two experienced measurement technicians were able to identify many of the treatment periods. They most often correctly identified aspirin, a drug with prominent effects and side effects. It is argued that in many circumstances it is better to use a blind observer who is not concerned with the giving of treatment or the collection of side effects.

摘要

在一项明显的双盲交叉研究中,两名经验丰富的测量技术人员能够识别出许多治疗阶段。他们最常正确识别出阿司匹林,一种具有显著疗效和副作用的药物。有人认为,在许多情况下,最好使用不参与治疗给药或副作用收集的盲法观察者。