双盲究竟有多“双盲”？这重要吗？
How double blind is double blind? And does it matter?
作者信息
Huskisson E C, Scott J
出版信息
Br J Clin Pharmacol. 1976 Apr;3(2):331-2. doi: 10.1111/j.1365-2125.1976.tb00612.x.
Abstract
In an apparently double blind crossover study, two experienced measurement technicians were able to identify many of the treatment periods. They most often correctly identified aspirin, a drug with prominent effects and side effects. It is argued that in many circumstances it is better to use a blind observer who is not concerned with the giving of treatment or the collection of side effects.
摘要
在一项明显的双盲交叉研究中，两名经验丰富的测量技术人员能够识别出许多治疗阶段。他们最常正确识别出阿司匹林，一种具有显著疗效和副作用的药物。有人认为，在许多情况下，最好使用不参与治疗给药或副作用收集的盲法观察者。
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本文引用的文献
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Placebos in the treatment of rheumatoid arthritis and other rheumatic conditions.安慰剂在类风湿关节炎及其他风湿性疾病治疗中的应用
Ann Rheum Dis. 1957 Mar;16(1):18-22. doi: 10.1136/ard.16.1.18.
2
Comparison of azathioprine, cyclophosphamide, and gold in treatment of rheumatoid arthritis.硫唑嘌呤、环磷酰胺和金制剂治疗类风湿关节炎的比较。
Br Med J. 1974 Sep 28;3(5934):763-6. doi: 10.1136/bmj.3.5934.763.
3
Simple analgesics for arthritis.用于关节炎的简单镇痛药。
Br Med J. 1974 Oct 26;4(5938):196-200. doi: 10.1136/bmj.4.5938.196.
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