用于关节炎的简单镇痛药。
Simple analgesics for arthritis.
作者信息
Huskisson E C
出版信息
Br Med J. 1974 Oct 26;4(5938):196-200. doi: 10.1136/bmj.4.5938.196.
A series of experiments has been carried out with single doses of simple analgesics in patients with rheumatoid arthritis using a consistent polyad design. This method proved to be both valid and useful. Pain relief scores were a better measure of the effectiveness of analgesics than preference.Aspirin, Codis, and Distalgesic were the most effective analgesics tested, with paracetamol, pentazocine, and Ciba 44,328 intermediate between these agents and placebo. Placebo given after an active analgesic was more effective than when given before; this phenomenon was not abolished by telling the patients that apparently identical tablets were, in fact, different or by making them different in colour. The effectiveness of soluble placebo depended on its colour, red being the most effective.
采用一致的多组设计，对类风湿性关节炎患者使用单剂量的简单镇痛药进行了一系列实验。该方法被证明既有效又有用。疼痛缓解评分比偏好更能衡量镇痛药的有效性。阿司匹林、可多睡（Codis）和痛力克（Distalgesic）是所测试的最有效的镇痛药，对乙酰氨基酚、喷他佐辛和汽巴44328的效果介于这些药物和安慰剂之间。在服用活性镇痛药后给予安慰剂比在服用前给予更有效；即使告知患者看似相同的片剂实际上不同，或者使它们颜色不同，这种现象也不会消除。可溶性安慰剂的有效性取决于其颜色，红色最有效。
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