Théon A P, Van Vechten M K, Feldman E
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616-8745.
Am J Vet Res. 1994 Dec;55(12):1734-8.
One hundred twenty cats with hyperthyroidism were treated with radioiodine (131I); 60 cats were administered radioiodine SC, and 60 cats were administered radioiodine IV. Before treatment, radioactive tracer studies were performed on each cat to determine peak radioactive iodine uptake and effective half-life. These data were used to calculate the dose of radioiodine that would have to be given to each cat to deliver 150 Gy to the thyroid tissue. The 2 groups of cats were similar with regard to age, tracer study results, and radioiodine dose. Mean estimated thyroid mass was larger for cats treated IV, but mean serum thyroxine concentration was higher for cats treated SC. Route of administration did not affect thyroidal uptake of radioiodine. However, radiation exposure of personnel was significantly lower with SC administration than with IV administration, even when IV catheterization was performed Eighty-five percent of cats treated IV and 84% of cats treated SC were euthyroid 4 years after treatment. Six percent of the cats became hypothyroid after treatment. When compared with IV administration, SC administration of radioiodine appeared to be as effective for treatment of hyperthyroidism, safer to personnel, and less stressful to the cats.
120只患有甲状腺功能亢进的猫接受了放射性碘（131I）治疗；60只猫接受放射性碘皮下注射，60只猫接受放射性碘静脉注射。治疗前，对每只猫进行放射性示踪剂研究，以确定放射性碘的摄取峰值和有效半衰期。这些数据用于计算每只猫为使甲状腺组织接受150戈瑞所需给予的放射性碘剂量。两组猫在年龄、示踪剂研究结果和放射性碘剂量方面相似。接受静脉注射治疗的猫的平均估计甲状腺质量较大，但接受皮下注射治疗的猫的平均血清甲状腺素浓度较高。给药途径不影响放射性碘的甲状腺摄取。然而，即使进行了静脉插管，皮下给药时工作人员受到的辐射暴露也显著低于静脉给药。治疗4年后，85%接受静脉注射治疗的猫和84%接受皮下注射治疗的猫甲状腺功能恢复正常。6%的猫在治疗后出现甲状腺功能减退。与静脉给药相比，皮下注射放射性碘治疗甲状腺功能亢进似乎同样有效，对工作人员更安全，对猫的压力也更小。
