Suppr超能文献

通过转移非免疫性白细胞诱导对可移植性小鼠浆细胞瘤的抗性或增强其抗性

Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes.

作者信息

Giovarelli M, Comoglio P M, Forni G

出版信息

Br J Cancer. 1976 Sep;34(3):233-8. doi: 10.1038/bjc.1976.157.

DOI:10.1038/bjc.1976.157
PMID:788762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2025188/
Abstract

Newborn mice have a lower spontaneous resistance to the growth of a syngeneic plasmacytoma (MOPC-460) as compared to adult mice. The transfer of different leucocyte populations from non-immunized adult donors to newborn mice influence in a dual way the resistance to MOPC-460 growth, depending on the number of cells transferred. The transfer of a low number of neutrophils, thymus or spleen cells enhances the MOPC-460 takes. Higher numbers of neutrophils, thymus or bone marrow cells induce an effective protenction. By contrast, macrophages over a dose of 1 X 10(4) constantly produce a reduction of tumour growth.

摘要

与成年小鼠相比，新生小鼠对同基因浆细胞瘤（MOPC-460）生长的自发抵抗力较低。将未免疫成年供体的不同白细胞群体转移到新生小鼠体内，根据转移细胞的数量，以双重方式影响对MOPC-460生长的抵抗力。转移少量中性粒细胞、胸腺或脾细胞可增强MOPC-460的接种成功率。较高数量的中性粒细胞、胸腺或骨髓细胞可诱导有效的保护作用。相比之下，超过1×10⁴剂量的巨噬细胞会持续导致肿瘤生长减少。

相似文献

1
Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes.通过转移非免疫性白细胞诱导对可移植性小鼠浆细胞瘤的抗性或增强其抗性
Br J Cancer. 1976 Sep;34(3):233-8. doi: 10.1038/bjc.1976.157.
2
Effector and enhancing lymphoid cells in plasmacytoma-bearing mice. II. Dynamic changes during tumor progression.携带浆细胞瘤小鼠中的效应和增强性淋巴细胞。II. 肿瘤进展过程中的动态变化。
Int J Cancer. 1980 Apr 15;25(4):493-501. doi: 10.1002/ijc.2910250411.
3
Effector and enhancing lymphoid cells in plasmacytoma-bearing mice. I. Methodological studies on the Winn assay.携带浆细胞瘤小鼠的效应和增强性淋巴细胞。I. 温氏试验的方法学研究。
Int J Cancer. 1980 Apr 15;25(4):487-92. doi: 10.1002/ijc.2910250410.
4
The allogeneic effect on tumor growth. I. Inhibition of a murine plasmacytoma, MOPC 315, by the graft-vs-host reaction.
J Immunol. 1977 Apr;118(4):1441-8.
5
The allogeneic effect on tumor growth. II. Suppression of both ascitic and solid MOPC 315 plasmacytoma by the graft-vs-host reaction, with pathologic correlation.同种异体对肿瘤生长的影响。II. 移植物抗宿主反应对腹水型和实体型MOPC 315浆细胞瘤的抑制作用及其病理相关性。
J Immunol. 1977 Apr;118(4):1449-55.
6
Effect of subcutaneously administered 2,6,10,14-tetramethylpentadecane on plasmacytoma growth.皮下注射2,6,10,14-四甲基十五烷对浆细胞瘤生长的影响。
Cancer Res. 1980 Jul;40(7):2229-33.
7
Regulation of immune responses aginst the syngeneic ADJ-PC-5 plasmacytoma in BALB-c mice. III. Induction of specific T suppressor cells to the BALB/c plasmacytoma ADJ-PC-5 during early stages of tumorigenesis.BALB-c小鼠针对同基因ADJ-PC-5浆细胞瘤免疫反应的调节。III.肿瘤发生早期对BALB/c浆细胞瘤ADJ-PC-5特异性T抑制细胞的诱导。
Immunology. 1982 Nov;47(3):503-10.
8
Immunological enhancement of tumor growth by syngeneic thymus-derived lymphocytes.
Transplantation. 1974 Sep;18(3):244-50. doi: 10.1097/00007890-197409000-00007.
9
Induction by cyclophosphamide administration of two distinct anti-tumor effector cells at tumor site and spleen of mice transplanted with MOPC-104E plasmacytoma.通过给予环磷酰胺在移植有MOPC - 104E浆细胞瘤的小鼠的肿瘤部位和脾脏诱导出两种不同的抗肿瘤效应细胞。
J Clin Lab Immunol. 1989 May;29(1):37-43.
10
Regulation of immune responses against the syngeneic ADJ-PC-5 plasmacytoma in BALB/c mice. II. Suppression of T-cell cytotoxicity by pretreatment of mice with subimmunogenic doses of tumour cells.BALB/c小鼠针对同基因ADJ-PC-5浆细胞瘤免疫反应的调节。II. 用亚免疫原性剂量的肿瘤细胞预处理小鼠对T细胞细胞毒性的抑制作用。
Immunology. 1981 May;43(1):145-52.

引用本文的文献

1
Strategies for cytokine utilisation in tumor therapy.肿瘤治疗中细胞因子的应用策略。
Med Oncol Tumor Pharmacother. 1993;10(1-2):53-9. doi: 10.1007/BF02987769.
2
Macrophages and antitumor reactions.巨噬细胞与抗肿瘤反应。
Cancer Immunol Immunother. 1983;16(2):67-71. doi: 10.1007/BF00199233.

本文引用的文献

1
Role of macrophages in immunological maturation.巨噬细胞在免疫成熟中的作用。
J Exp Med. 1968 Sep 1;128(3):459-67. doi: 10.1084/jem.128.3.459.
2
Effect of age upon primary alloantigen recognition by mouse spleen cells.年龄对小鼠脾细胞识别主要同种异体抗原的影响。
J Immunol. 1971 Nov;107(5):1357-67.
3
Effect of spleen cells on cytotoxicity by immune lymph node cells: cell-mediated immune suppression (? enhancement) in vitro.脾细胞对免疫淋巴结细胞细胞毒性的影响：体外细胞介导的免疫抑制（？增强）
J Immunol. 1972 Jul;109(1):51-8.
4
The influence of the thymus on the development of transplanted mammary tumour in mice.胸腺对小鼠移植性乳腺肿瘤生长发育的影响。
Int J Cancer. 1972 Jan 15;9(1):1-7. doi: 10.1002/ijc.2910090102.
5
The immune reaction as a stimulator of tumor growth.作为肿瘤生长刺激因素的免疫反应。
Science. 1972 Apr 14;176(4031):170-1. doi: 10.1126/science.176.4031.170.
6
An immunostimulation theory of tumor development.肿瘤发生的免疫刺激理论。
Transplant Rev. 1971;7:26-54. doi: 10.1111/j.1600-065x.1971.tb00462.x.
7
Immune stimulation-inhibition of experimental cancer metastasis.
Cancer Res. 1974 Mar;34(3):491-8.
8
In vitro studies of cellular-mediated immunostimulation of tumor growth.
J Natl Cancer Inst. 1973 May;50(5):1307-12. doi: 10.1093/jnci/50.5.1307.
9
The lymphocyte response to primary Moloney sarcoma virus tumors in BALB-c mice. Definition of the active subpopulations at different times after infection.BALB-c小鼠对原发性莫洛尼肉瘤病毒肿瘤的淋巴细胞反应。感染后不同时间活性亚群的定义。
J Exp Med. 1973 Jun 1;137(6):1472-93. doi: 10.1084/jem.137.6.1472.
10
Growth of syngeneic tumours in unimmunized newborn and adult hosts.同基因肿瘤在未免疫的新生和成年宿主中的生长。
Br J Cancer. 1973 Feb;27(2):120-7. doi: 10.1038/bjc.1973.16.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验