Larsson C, Thomsen P, Lausmaa J, Rodahl M, Kasemo B, Ericson L E
Department of Anatomy and Cell Biology, University of Göteborg, Sweden.
Biomaterials. 1994 Oct;15(13):1062-74. doi: 10.1016/0142-9612(94)90092-2.
In a series of experimental studies, bone formation was analysed around systematically modified titanium implants. In the present study, machined, electropolished and anodically oxidized implants were prepared, surface characterized and inserted in the cortical bone of rabbits (7 wks and 12 wks). SEM, scanning Auger electron spectroscopy and atomic force microscopy revealed no differences in surface composition but marked differences in oxide thickness, surface topography and roughness. Light microscopic morphology and morphometry showed that all implants were in contact with bone, and had a large proportion of bone within the threads. The smooth, electropolished implants were surrounded by less bone than the machined implants with similar oxide thickness, (4-5 nm) and the anodically oxidized implants with thicker oxides (21 nm and 180 nm, respectively) after 7 wks. These studies show that a high degree of bone contact and bone formation can be achieved with titanium implants which are modified with respect to oxide thickness and surface topography. However, it appears that a reduction of surface roughness may influence the rate of bone formation in rabbit cortical bone.
在一系列实验研究中，对经过系统改性的钛植入物周围的骨形成情况进行了分析。在本研究中，制备了机械加工、电解抛光和阳极氧化的植入物，对其表面进行了表征，并将其植入兔（7周龄和12周龄）的皮质骨中。扫描电子显微镜（SEM）、扫描俄歇电子能谱和原子力显微镜显示，表面成分没有差异，但氧化物厚度、表面形貌和粗糙度存在显著差异。光学显微镜形态学和形态测量学表明，所有植入物均与骨接触，且螺纹内有很大比例的骨。在7周后，表面光滑的电解抛光植入物周围的骨量比氧化物厚度相似（4-5纳米）的机械加工植入物以及氧化物更厚（分别为21纳米和180纳米）的阳极氧化植入物少。这些研究表明，通过对氧化物厚度和表面形貌进行改性的钛植入物可以实现高度的骨接触和骨形成。然而，表面粗糙度的降低似乎可能会影响兔皮质骨中的骨形成速率。
